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Reality of COVID-19 Vaccine | Dhruv Rathee

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Greetings, friends!India has now jumped onto rank 3 in the world, with regard to the total number of corona virus casesThat is, India has seen the most number of corona virus cases after USA and BrazilThere is no doubt about the fact that there is an urgent need for a vaccine for COVID 19The sooner a vaccine is developed, the more people we would be able to saveBut how soon can a vaccine be developed?Baba Ramdev has already launched his treatment: Coronil- which promises 100% recovery within 7 daysThis is what he claimsA lot of controversy ensued and several questions were raisedAn FIR was also lodged against Baba Ramdev regarding thisand Coronil has even been banned in some statesOn the other hand, Indian Council of Medical Research has been hoping that by 15th August,that is, by our Independence day,India will launch the world’s first made in India COVID 19 vaccineIs it realistically possible?And what is the status of COVID 19 vaccine in the rest of the countries?Come, let us find out about all these things in today’s videoAs always, let us begin with the basics firstWhat are vaccines and how do they work?Vaccines are basically something like a “mock exam”Before you write the board exams, you first appear for the pre-boardsin order to prepare yourself well for the real board examSo, vaccines are these “pre-board” examsWhat happens is that when a virus enters your body to infect it,Actually, not a virus, I would use the word “pathogen””Pathogen” includes everything- virus, bacteria, protozoa and all the disease causing microbesNormally, when pathogens attack/infect our body, then our immune system respondsOur immune system has three main jobsThe first is detecting these pathogensSecond- to remove these pathogens from our body and wage a war against themThis is done by the White blood cells within our bodyYou could consider the White blood cells to be the personal army of our bodyThey fight the pathogen and remove them from the bodyAnd when this happens, then our body starts showing symptomsFor example, fever, cough and coldAll these symptoms show that our body is fighting against this virus and is removing it from the bodythat it is trying to remove the pathogen from our bodyWhite blood cells release antibodies against the pathogens in order to do thisThe third job of the immune system is to memorizeThat is, to remember how to react and fight against a pathogen that it has already encountered onceVaccines prepare our bodies beforehand, just like a mock examIt helps the body in recognizing the pathogen and in creating a memory of how to fight it and remove it from the bodySo that when that pathogen actually enters the body, then our body is already prepared to fight itand there is already a stored memory of how to generate an antibody against it and remove it from the bodySo that our immune system is able to fight the pathogen more effectively and within a shorter span of timedue to vaccinesNow, you could ask what is it in the vaccines that it prepares our body to fight?The answer to this is quite simpleVery often, the pathogen itself is present in the vaccine, albeit in different statesIn some vaccines, the pathogen is killed and its dead body is present in itSometimes, the pathogen is weakened and is present in the vaccineSometimes, the pathogen is cut into fragments and some of its parts are present inside the vaccineSo, there are different kinds of vaccines that can be madeand each of them have their own pros and consIf the vaccine is developed by weakening the pathogen, without killing it entirely,then this type of vaccine is called “live attenuated vaccine”This type of vaccine is used against diseases like small pox and chicken poxIts pros include the fact that it is extremely effectiveIts cons include the fact that it takes a very long time to developOn the other hand, if a vaccine is developed by killing a pathogen and by using its dead body,then this type of vaccine is called “inactivated vaccine”This type of vaccine is used against flu, polio and rabiesIts disadvantage is that it does not provide a very strong, long lasting immunityTheir doses need to be repeatedFor example, if you were administered the polio vaccine, then it would have been repeated year after yearThis is its disadvantageThe third type of vaccine makes use of the different fragments of the pathogenThis type of vaccine is called a “subunit vaccine”which is used in the vaccines against Hepatitis B and HBV vaccinesThese are the three general categories of vaccines. There are even more types of vaccinesAll I’m trying to do here is to provide you with a general overviewThere have been very few human achievements or technology that has saved human lives in the numbers that vaccines haveIt’s hard to believe, but around 250 years ago, in the 1700s, before the invention of vaccines,the child mortality rate of children under 5 years was around 40-50%That is, 200 years ago, if a woman gave birth to a child,then there would be a 50% chance that the child would die before it reached the age of 5This rate of child mortality has fallen below even 1% in developed countries todaySo you can imagine the number of lives that have been saved due to these vaccinesSo, now a question arises- How long does it take to develop a vaccine?The answer to this is that it normally takes around 10 yearsBut the speed with which work has been progressing on the COVID19 vaccine, experts say thatkeeping this speed in mind, the vaccine might be developed within one to one and a half yearsThe fastest vaccine to have ever been made was that of mumps which took around 5 years to developOn the other hand, there is an HIV vaccine, which has not been developed until nowIt is being predicted that it would be ready by 2030It would have taken 50 years to develop if it is ready by 2030!This is how long it can take to develop vaccinesThere are three main stages in the preparation of a vaccineThe first is the research stage where the scientists research to find outthe different ways in which the vaccine could be developedShould they develop a live attenuated vaccine or something else?Which option is safer, which is not?- All of this is researched uponThe second stage is the testing stagewhere the effectiveness and the safety of the vaccine chosen is testedWithin the testing stage, there are different stages- The first is pre-clinical trialsThese are those trials where testing is done on cells within a laboratory or on animalsThe vaccine is tested on animals first to see whether the vaccine is effective and safe or notFollowing which, testing on humans commence. These tests are called clinical trialsThere are four different phases in the clinical trialsVery few people are tested upon in the first phase to test its effectiveness and safenessIn the second phase, a few hundred people are tested upon for a few monthsTo study the dosage that needs to be administered and what the intensity of the vaccine is against the pathogenIn the third phase, it is tested upon thousands of peopleand then measure the safety it provides on a large scaleand whether there are any side effects of the vaccine or notThe third phase can take years because the testing needs to be done for a long period of timeIf the vaccine is administered today and it is observed that it is working very effectively in the short term,but it could so happen that the administration of the vaccine might lead to very harmful effects one year laterWhat would happen then?This is why it needs to be tested for a long time. The side effects need to be monitored in the long termIt is sent for approval in phase 4. The government will provide a license and you will be allowed to manufacture the vaccineand then sell it to the people because it turned out to be effectiveThen comes the manufacturing stageThe approval has been granted and now factories need to be set up to produce the vaccine on a mass scaleand to deliver it to as many people as soon as possibleThis stage is not easy either. Because a lot of capital is required to set up a factoryAnd the procedure to manufacture vaccines in the factories is different for different vaccinesAnd since there are so many different types of vaccines and since it takes so long to manufacture them,So the best way out is that research is conducted in different labs and universities by different companiesThey all should develop the vaccine at their own pace and conduct their own testsSo that whosoever emerges out in the front later with the most successful testingscomes up with an authentic vaccineLet us now talk about the status of the COVID19 vaccineRight now, there are approximately around 100 vaccines under development across the worldwhich are in the pre clinical stageThe World Heath Organization has been tracking around 70 of these vaccinesAs you can see in this PDF, the first two columns tell us about what type of vaccine it isThe third column states who is developing it-a government agency, a university or a pharmaceutical companyThe second last column tells us which stage of development is the vaccine inMost of the vaccines are in the pre -clinical stage and some are in Phase 1 or phase 2 of clinical trialThis document is of April, thoughThe current status is that presently, there are 17 potential vaccines in the clinical trials stage across the worldin ten different countries and there is at least 1 vaccinewhich is already being used by the Chinese military in a limited mannerNow. I’d like to talk about some top potential vaccines on a country by country basiswhich are leading in the race to develop a vaccineThere are four potential candidates in USA that are under developmentand the vaccine produced by the Moderna company is first in the raceThey had begun with their human trials back in Marchand they were planning to start phase 3 of their clinical trialsAround 30,000 people would be tested upon in Phase 3but as per the latest news, their phase 3 trials have been slightly delayedA vaccine is being developed in Germany by the Pfizer and BioNTech companyThey conducted a clinical trial on 45 people and they found that when a 100 gram doseof their vaccine was being administered to patients, 50% patients out of thoseexperienced fever and sleep disturbances as a side effectalthough none of these side effects were life threateningI want to show you how when trials are conducted upon patients, then it is found outwhat the side effects of administering the vaccine areand how they can be reduced and what should be changedThey are also planning their Phase 3 clinical trials by the end of Julywhich will be conducted on around 30,000 peopleThis normally takes upto five years, but experts believe that if this process is sped up,by taking faster approvals, then it can be completed within one yearThe Oxford University in UK is developing a vaccine and most of the experts are of the opinion that today,at present, the vaccine being developed by the Oxford University is leading in the race to produce a vaccineTheir phase 2 trials have already been completedThey started their phase 3 trials on 20th June in Brazilin which they are testing it on 5,000 peopleThey believe that by the end of August they’d be able to say whether this vaccine will be successful or notIf is indeed successful, then by the beginning of 2021, it would become available in he marketsTalking of India, there is a vaccine named “Covaxin” which has been a beacon of hopeIt is being manufactured by a company called the Bharat Biotech, which is based in HyderabadThey already have been granted the approval to start with their human trialsAnd it is expected that they will start with their phase 1 and phase 2 trails this week itselfThis testing will be carries out on around 1,000 people in HyderabadBut to say that this vaccine will be ready by 15th August, is an extremely unrealistic expectationCompare it with the rest of the countries,phase 1 and phase 2 trials have been completed in some countries and quite some time ago in othersand phase 3 trials are set to beginSo, how can they begin as well as conclude all the three trials within one month in IndiaEven if they ignore the phase 3 trials and say that they will only carry out trials in two phaseseven that would take a period of a few monthsA letter of the Indian Council of Medical research has surfaced which states that, “it is envisagedto launch the vaccine for public health use latest by August 15th, 2020. “The same letter reads that this is the first indigenous vaccine being developed by Indiaand is one of the top priority projects which is being monitored at the topmost level of the governmentThis raises a question of whether pressure is being mounted on the companies and the scientiststo fast forward their clinical trials so that it can launch this vaccine on Independence dayto show off that India launched this vaccine for the world on its Independence dayThis question does not sound that unbelievablebecause such marketing stunts have been employed by the government in the pastFor example, the 20 lakh crore budget released at 20:20 in the year 2020in an attempt to align all these numbersSo this could be an attempt to say that they would give the country independence from corona on Independence dayIt is important to give science more priority that these marketing stuntsWhat use would it be to launch a vaccine which has not been properly tested?Even if we launch a vaccine without conducting clinical trials in a proper manner,if it is used and it is alter found out that is causes certain negative effects in the long term,What would happen then? Who would shoulder the blame?Sufficient time and testing is extremely necessary for the vaccine or elseit might have side effects which could be harmful for the health of the peopleAs for Patanjali, the less I talk about it, the better it isThe clinical trials that it claimed to have conducted to show its 100% recovery rate,the shortcomings, mistakes and the things that they have concealed in these clinical trialshave all been stated in this article by AltNewsI have provided its link in the description below. You can go read it if you wish toto know why the vaccine and the treatment of Patanjali is not correct scientificallyI hope you would have learnt new things from this video. Share itand if you liked this video, you can support me on Patreon. com/DhruvRatheeor by becoming a member on YouTube by clicking on the join button belowso that I may continue to make such videos for you in the future. In exchange for becoming a member,or a member on Patreon,You will get exclusive access to many things like unedited, full interviews whenever I conduct themWe will meet again in the next videoThank you

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